解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Deregulated cancer cell metabolism plays an important role in cancer progression. Cancer cell metabolism has been in the centre of attention in therapeutical cancer cell targeting. Repurposed chemical agents, such as metformin and aspirin, have been studied extensively as preventive and therapeutic agents. Metformin i...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117747025
更新日期:2018-09-01 00:00:00
abstract::In the 1980s, villages in the Kurdistan region of Iraq were exposed to chemical weapons (CWs), which killed and injured thousands of civilians. There has been no clinical assessment of the long-term effects of CWs exposure on those injured. We report the first such evaluation of CW effects on long-term health of child...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117734620
更新日期:2018-08-01 00:00:00
abstract::Rosiglitazone is in the thiazolidinedione class of drugs used in the treatment of type 2 diabetes mellitus. It works as an insulin sensitizer by binding to the peroxisome proliferator-activated receptor gamma. We investigated the effects of prenatally administered rosiglitazone on pyramidal cell numbers and morphologi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117730883
更新日期:2018-08-01 00:00:00
abstract:CONTEXT:Cardiac dysfunction is one of the most serious consequences of scorpion envenomation. The best tool to evaluate cardiac function is echocardiography, but it is not available at all emergency departments. Many studies aimed to describe biological predictive factors of cardiac dysfunction in scorpion envenomation...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117722822
更新日期:2018-06-01 00:00:00
abstract:INTRODUCTION:This study provides an epidemiological description of non-health care facility medication errors involving anticonvulsant drugs. METHODS:A retrospective analysis of National Poison Data System data was conducted on non-health care facility medication errors involving anticonvulsant drugs reported to US Po...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117721962
更新日期:2018-06-01 00:00:00
abstract::The use of Lucilia sericata larvae on the healing of wounds in diabetics has been reported. However, the role of the excretion/secretion (ES) products of the larvae in treatment of diabetic wounds remains unknown. This study investigated whether application of the ES products of L. sericata on the wound surface could ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117714041
更新日期:2018-05-01 00:00:00
abstract::The polybrominated diphenyl ether flame retardants decabromodiphenyl ether (BDE-209) and bisphenol A (BPA) are environmental contaminants that can cross the placenta and exert toxicity in the developing fetal nervous system. Copy number variants (CNVs) play a role in a number of genetic disorders and may be implicated...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117710535
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:The present study was designed to highlight the toxic impact of baclofen on both biochemical and histopathological aspects in rats' liver, gastric, lung, kidney, and brain tissues. METHODS:The study was performed on 30 healthy adult male albino rats divided into four groups with 5 rats in each control group,...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117712369
更新日期:2018-04-01 00:00:00
abstract::Pyrazinamide (PYZ)-an essential component of primary drug regimen used for the treatment and management of multidrug resistant or latent tuberculosis-is well known for its hepatoxicity. However, the mechanism of PYZ-induced hepatotoxicity is still unknown to researchers. Studies have shown that the drug is metabolized...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117705426
更新日期:2018-04-01 00:00:00
abstract::Arsenic trioxide (As2O3) is utilized for treating patients suffering from hematological malignancies particularly acute promyelocytic leukemia. Unfortunately, the extensive application of this chemotherapeutic agent has been limited due to its adverse effects such as cardiotoxicity. Ellagic acid, as a phenolic compoun...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117701986
更新日期:2018-04-01 00:00:00
abstract::Amyloid beta (Aβ) peptide aggregation and cholinergic neurodegeneration are involved in the development of cognitive impairment. Therefore, in this article, we examined rosuvastatin (RSV), an oral hypolipidemic drug, to determine its potential as a dual inhibitor of acetylcholinesterase (AChE) and Aβ peptide aggregati...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117705431
更新日期:2018-04-01 00:00:00
abstract::Genotoxicants can be identified as aneugens and clastogens through a micronucleus (MN) assay. The current high-content screening-based MN assays usually discriminate an aneugen from a clastogen based on only one parameter, such as the MN size, intensity, or morphology, which yields low accuracies (70-84%) because each...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117695635
更新日期:2018-03-01 00:00:00
abstract::The malignancy of non-small cell lung cancer (NSCLC) largely results from its invasive manner. Secreted frizzled-related proteins (SFRPs) have been recently found to suppress the invasiveness of some cancers. On the other hand, the methylation of SFRPs increases protein degradation to reduce the activity of SFRPs, res...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117693071
更新日期:2018-02-01 00:00:00
abstract::1-Bromopropane (1-BP) is an increasingly used chemical solvent for cleaning metals and gradually replacing spraying adhesives. Workers exposed to 1-BP (WBP) showed nervous system dysfunction and other symptoms. This study focused on the proteomic change between healthy individuals (HIs), WBP and poisoned patients with...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117689911
更新日期:2018-01-01 00:00:00
abstract::Postoperative cognitive dysfunction, which is associated with a wide range of cognitive functions including working memory, long-term memory, information processing, attention, and cognitive flexibility, is a major clinical issue in geriatric surgical patients. The aim of the current study was to determine the protect...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116688068
更新日期:2017-12-01 00:00:00
abstract::Teucrium polium L. (Lamiaceae) is a commonly used medicinal plant in folk medicine. Among several uses, T. polium is used to treat male fertility problems. This research was conducted to study the effect of T. polium on spermatogenesis, testosterone level, androgen receptor expression, and fertility in male rats. Admi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116688069
更新日期:2017-12-01 00:00:00
abstract::Hypofibrinogenemia is an important clinical consequence following envenomation by Lachesis muta muta, usually attenuated or prevented by administration of antivenom. The venom of L. m. muta contains both a metalloproteinase fibrinogenase and a serine protease thrombin-like enzyme, and exposure of fibrinogen to iron (F...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116661401
更新日期:2017-07-01 00:00:00
abstract::Acute exposure to systemic poisons represents an important challenge in clinical toxicology. We aimed to analyze the potential role of cardiac biomarkers, routine laboratory tests, and clinical scores as morbidity and in-hospital mortality predictors in patients intoxicated with various systemic poisons. We conducted ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116660866
更新日期:2017-07-01 00:00:00
abstract:INTRODUCTION:Anthrax is a bacterial disease caused by the aerobic sporeforming bacterium Bacillus anthracis. It has been suggested that oxidative stress plays an important role in the pathogenesis of B. anthracis. The aim of this study was to investigate serum paraoxonase 1 (PON1) activity, catalase activity, malondial...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116661020
更新日期:2017-07-01 00:00:00
abstract::There are many discrepancies among the results of studies on the genotoxicity of lead. The aim of the study was to explore lead-induced DNA damage, including oxidative damage, in relation to oxidative stress intensity parameters and the antioxidant defense system in human leukocytes. The study population consisted of ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116665674
更新日期:2017-07-01 00:00:00
abstract::This study was designed to determine the levels of prolactin, leptin, osteopontin, and follistatin in workers chronically and subacutely exposed to lead compounds. The examined population consisted of three groups. The first group was composed of 56 male workers who were chronically exposed to lead for 13.38 ± 10.38 y...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116658106
更新日期:2017-06-01 00:00:00
abstract::Endogenous alcohol has been applied for spontaneous ethanol production via different metabolic pathways of the human body. Auto-brewery syndrome describes the patients with alcohol intoxication after ingesting carbohydrate-rich meals. The main objective of this study is to investigate the effect of diabetes mellitus (...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116661400
更新日期:2017-05-01 00:00:00
abstract::Naringenin is a naturally occurring flavanones and has been found to exhibit free radical scavenging, enzyme inhibition, antioxidants, anti-inflammatory, and anticancer activities. Present study was designed to evaluate the protective role of naringenin against benzo[a]pyrene (B[a]P)-induced oxidative stress and pulmo...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116650009
更新日期:2017-04-01 00:00:00
abstract::Hepatic fibrosis is a leading cause of morbidity and mortality worldwide. Attenuation of fibrogenic process can significantly lower the mortality rate. However, pharmaceutical intervention at fibrogenesis stage remains a major task in medicine. So there is a need for a natural compound to treat hepatic fibrosis. This ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116638727
更新日期:2017-02-01 00:00:00
abstract::This study was designed to evaluate the hepato and neuroprotective activity of Daflon and low-dose γ radiation on thioacetamide (TAA)-induced liver damage and hepatic encephalopathy (HE) in rats. Effect of daily Daflon treatment (100 mg/kg body weight, Per OS (p.o.) for consecutive 3 days) and/or fractionated low-dose...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116637657
更新日期:2017-01-01 00:00:00
abstract::Pentavalent antimonial (Sb5+) drugs such as meglumine antimoniate (MA) are the mainstay treatment of leishmaniases in developing countries. The effects of these compounds on drug-metabolizing enzymes have not been characterized and their potential pharmacokinetic interactions with other drugs are therefore unknown. Th...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116637110
更新日期:2017-01-01 00:00:00
abstract::In vivo antidotal efficacy of new bis- quaternary 2-(hydroxyimino)- N-(pyridin-3yl) acetamide derivatives (HNK series), to counter multiples of lethal doses of nerve agent sarin (GB) and reactivation of acetylcholinesterase (AChE), was evaluated in Swiss albino mice. [Protection index PI; median lethal dose (LD50) of ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116637109
更新日期:2017-01-01 00:00:00
abstract::The purpose of this study was to characterize the zinc oxide nanoparticles (ZnO-NPs) and their bulk counterpart in suspensions and to access the impact of their acute oral toxicity at doses of 300 and 2000 mg/kg in healthy female Wistar rats. The hematological, biochemical, and urine parameters were accessed at 24 and...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116629530
更新日期:2016-12-01 00:00:00
abstract::Nicotinamide riboside (NR) is a naturally occurring form of vitamin B3 present in trace amounts in some foods. Like niacin, it has been shown to be a precursor in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). The safety of Niagen™, a synthetic form of NR, was determined using a bacterial reverse mutage...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115626254
更新日期:2016-11-01 00:00:00
abstract:AIM:Diazinon (DZN) is one of the most important organophosphorus compounds used to control pests in agriculture in many countries. Several studies have shown that exposure to DZN may alter protein expression in the liver. In order to further investigate the mechanism of DZN toxicity, differentially expressed ATP-intera...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115619771
更新日期:2016-10-01 00:00:00
abstract::Periodontitis is a common infectious disease associated with destruction of periodontal ligaments and alveolar bones. CD4(+) T cell-mediated immune response is involved in the progression of periodontitis. Tobacco consumption increases the risk of periodontal disease. However, the impact of nicotine on the interaction...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115614383
更新日期:2016-09-01 00:00:00
abstract::In this study, we aimed to investigate disulfide/thiol homeostasis in trichloroethylene (TCE) exposure. The study was carried out in 30 nonsmoker TCE-exposed workers with a variety of occupations. Additionally, 30 healthy nonsmoker volunteers were recruited as the control group. TCE exposure was determined by measurin...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115608928
更新日期:2016-09-01 00:00:00
abstract::This study investigated the main target sites of chlorpyrifos (CPF), its effect on biochemical indices, and the pathological changes observed in rat liver and kidney function using gas chromatography/mass spectrometry. Adult female Wistar rats (n = 12) were randomly assigned into two groups (one control and one test g...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115614384
更新日期:2016-09-01 00:00:00
abstract::Vigabatrin (VGB) is an antiepileptic drug thatincreases brain γ-aminobutyric acid (GABA) levels through irreversible inhibition of GABA transaminase. The aim of this study was to evaluate neurotoxicological effects of VGB measuring motor activity and genotoxic and mutagenic effects after a single and repeated administ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115611970
更新日期:2016-09-01 00:00:00
abstract::The second-generation selective 5-HT2 receptor antagonists and reuptake inhibitors (SARIs) class antidepressants are known to have fewer cardiovascular side effects than the older ones. However, several case reports showed that trazodone, one of the second-generation SARIs, induces QT prolongation, cardiac arrhythmia,...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115595683
更新日期:2016-05-01 00:00:00
abstract::This study was designed to investigate the effect of agmatine sulfate (AG, CAS2482-00-0) in nicotine (NIC)-induced vascular endothelial dysfunction (VED) in rabbits. NIC was administered to produce VED in rabbits with or without AG for 6 weeks. Serum lipid profile, serum thiobarbituric acid reactive substances, reduce...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115597311
更新日期:2016-05-01 00:00:00
abstract::The purpose of the present study is to establish a new animal model of azithromycin (AZ)-induced liver injury and study the molecular pathological change during the process. First, mice were respectively injected intraperitoneally with AZ of different high doses. Our results showed that 800 mg/kg AZ injection signific...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115595684
更新日期:2016-05-01 00:00:00
abstract::Stem cell transplantation has indicated great promise for cell therapy in a wide range of diseases, but poor and insufficient viability of cells within damaged tissues has limited its potential therapeutic effects. 17 β-Estradiol (E2) is a steroid hormone that plays an important role in expression of many genes and re...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115586208
更新日期:2016-03-01 00:00:00
abstract:INTRODUCTION:Accidental toxicity by organophosphate (OP) agents may occur among farmers during spraying season due to improper use and handling. Plasma cholinesterase (ChE) activity measurement is recommended to monitor the extent of exposure to the OP agent. The aim of the current study was to measure plasma ChE activ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115584990
更新日期:2016-03-01 00:00:00
abstract::We aimed to investigate the possible roles of nitric oxide (NO) and endothelin on the changes of cardiac muscle function in both hyper- and hypodynamic septic shock periods. Cecal ligation and puncture was performed in 50 Wistar albino rats to induce septic shock. Changes in atrium and right ventricle papillary muscle...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115583363
更新日期:2016-03-01 00:00:00